Carbimazole induced acute generalised exanthematous pustulosis
نویسندگان
چکیده
Background Acute generalised exanthematous pustulosis (AGEP) also known as pustular drug eruption is an unusual drug induced hypersensitivity skin manifestation, characterized by acute onset of fever, and numerous non-follicular pinhead sterile pustules on erythematous background , usually over the flexural areas and face [1]. Neutrophils are involved in the pathogenesis of AGEP. Neutrophilactivating cytokines like IL-3 and IL-8 have been implicated [2]. Around 90 percent of the times AGEP is caused by a drug. Reported most often due to antibacterials. Carbimazole which is a thiourea antithyroid drug is not one of the usual suspect.
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